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Showing 1–2 of 2 results
Advanced filters: Author: Melanie Jambeau Clear advanced filters

  • Repeat-associated non-AUG (RAN) translation contributes to the pathogenic mechanism of several microsatellite expansion diseases. Here the authors delineate the different steps involved in recruiting the ribosome to initiate G4C2 RAN translation to produce poly-Glycine Alanine, poly-Glycine Proline, and poly-Glycine Arginine repeats.

    • Ricardos Tabet
    • Laure Schaeffer
    • Clotilde Lagier-Tourenne
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • TDP-43 aggregation is observed in amyotrophic lateral sclerosis. Here the authors combine X-ray crystallography, nuclear magnetic resonance and electron microscopy studies and show that physiological oligomerization of TDP-43 is mediated through its N-terminal domain, which forms functional and dynamic oligomers antagonizing pathologic aggregation.

    • Tariq Afroz
    • Eva-Maria Hock
    • Magdalini Polymenidou
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15