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Showing 1–4 of 4 results
Advanced filters: Author: Melanie Weisser Clear advanced filters

  • Initiation factors eIF1 and eIF1A are key determinants of ribosomal scanning and initiation-codon selection during translation initiation. The structure of Tetrahymena thermophila 40S ribosome in complex with eIF1 and eIF1A reveals the conformational changes that accompany initiation-factor binding and provides new insights into the mechanism of start-codon recognition.

    • Melanie Weisser
    • Felix Voigts-Hoffmann
    • Nenad Ban
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1015-1017

  • p97/VCP, a nexus of the ubiquitin system, recognizes and unfolds ubiquitylated substrates via multiple cofactors. Here, the authors identify VCF1, a nuclear cofactor promoting p97 recruitment to, and proteasomal degradation of, ubiquitylated targets.

    • Ann Schirin Mirsanaye
    • Saskia Hoffmann
    • Niels Mailand
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.

    • Woranop Sukparangsi
    • Elena Morganti
    • Joshua M. Brickman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Land use intensification is a major driver of biodiversity change. Here the authors measure diversity across multiple trophic levels in agricultural grassland landscapes of varying management, finding decoupled responses of above- and belowground taxa to local factors and a strong impact of landscape-level land use.

    • Gaëtane Le Provost
    • Jan Thiele
    • Peter Manning
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13