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Showing 1–5 of 5 results
Advanced filters: Author: Melanie Werner-Klein Clear advanced filters
  • Guetter et al. identify a melanoma-associated chondroitin sulfate proteoglycan-positive subpopulation of metastasis founder cells from lymph node biopsies of patients with melanoma and observe that they mediate immune evasion and predict systemic metastasis and poor outcomes.

    • Severin Guetter
    • Courtney König
    • Melanie Werner-Klein
    ResearchOpen Access
    Nature Cancer
    Volume: 6, P: 1017-1034
  • Metastatic dissemination in breast cancer patients occurs early in malignant transformation, raising questions about how disseminated cancer cells (DCC) progress at distant sites. Here, the authors show that DCCs in bone marrow are activated via IL6-trans-signaling and thereby acquire stemness traits relevant for metastasis formation.

    • Melanie Werner-Klein
    • Ana Grujovic
    • Christoph A. Klein
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18
  • It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.

    • Melanie Werner-Klein
    • Christoph A. Klein
    News & Views
    Nature Cell Biology
    Volume: 21, P: 117-119
  • Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

    • Hedayatollah Hosseini
    • Milan M. S. Obradović
    • Christoph A. Klein
    Research
    Nature
    Volume: 540, P: 552-558