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Advanced filters: Author: Melbert-Brian Decipulo Saflor Clear advanced filters

  • GPR40 is a G-protein coupled receptor that binds to free fatty acids, mediating insulin and incretin secretion. Here, the authors present the crystal structure of human GPR40 with an agonist bound to an allosteric site located near the lipid-rich region that suggests a mechanism for biased agonism.

    • Joseph D. Ho
    • Betty Chau
    • Chafiq Hamdouchi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11