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Showing 1–5 of 5 results

Advanced filters: Author: Melek C. Arkan Clear advanced filters

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Chemotherapy-induced death of colon cancer cells causes ATP release triggering P2X4 to mediate an mTOR-dependent pro-survival program in neighbouring cancer cells, which renders them sensitive to mTOR inhibition.

Mark Schmitt
Fatih Ceteci
Florian R. Greten
Research16 Nov 2022
Nature

Volume: 612, P: 347-353
IKK-β links inflammation to obesity-induced insulin resistance

Melek C Arkan
Andrea L Hevener
Michael Karin
Research30 Jan 2005
Nature Medicine

Volume: 11, P: 191-198
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation.

Manon D. Schulz
Çiğdem Atay
Melek C. Arkan
Research31 Aug 2014
Nature

Volume: 514, P: 508-512
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Gut microbial carcinogen metabolism: another avenue to cancer

Florian R. Greten
Melek C. Arkan
Research HighlightsOpen Access28 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-2