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Showing 1–2 of 2 results
Advanced filters: Author: Melinda K. Wheelock Clear advanced filters

  • Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess variant effects in secreted proteins at scale.

    • Nicholas A. Popp
    • Rachel L. Powell
    • Douglas M. Fowler
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 2099-2111

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57