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Showing 1–5 of 5 results
Advanced filters: Author: Melissa Reding Clear advanced filters

  • A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional changes and the interaction of ageing and disease.

    • Kelly Jin
    • Zizhen Yao
    • Hongkui Zeng
    ResearchOpen Access
    Nature
    Volume: 638, P: 182-196

  • A large, open dataset containing parallel recordings from six visual cortical and two thalamic areas of the mouse brain is presented, from which the relative timing of activity in response to visual stimuli and behaviour is used to construct a hierarchy scheme that corresponds to anatomical connectivity data.

    • Joshua H. Siegle
    • Xiaoxuan Jia
    • Christof Koch
    Research
    Nature
    Volume: 592, P: 86-92

  • A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

    • Jeremy A. Miller
    • Song-Lin Ding
    • Ed S. Lein
    Research
    Nature
    Volume: 508, P: 199-206

  • A high-resolution gene expression atlas of prenatal and postnatal brain development of rhesus monkey charts global transcriptional dynamics in relation to brain maturation, while comparative analysis reveals human-specific gene trajectories; candidate risk genes associated with human neurodevelopmental disorders tend to be co-expressed in disease-specific patterns in the developing monkey neocortex.

    • Trygve E. Bakken
    • Jeremy A. Miller
    • Ed S. Lein
    Research
    Nature
    Volume: 535, P: 367-375

  • Laser microdissection and microarrays are used to assess 900 precise subdivisions of the brains from three healthy men with 60,000 gene expression probes; the resulting atlas allows comparisons between humans and other animals, and will facilitate studies of human neurological and psychiatric diseases.

    • Michael J. Hawrylycz
    • Ed S. Lein
    • Allan R. Jones
    Research
    Nature
    Volume: 489, P: 391-399