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BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4⁺ T-cell exhaustion

Acute-on-chronic liver failure (ACLF) is characterized by rapid deterioration of liver function in patients with chronic liver disease. Here, the authors show that BTLA expression in CD4⁺ T cells is associated with disease severity and inflammation in hepatitis B virus-related ACLF.

Xueping Yu
Feifei Yang
Jiming Zhang
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface

Cryo-electron microscopy structures reveal the mechanisms underlying multiple-substrate specificity, coupling of epoxidation with carboxylation and allosteric motions during VKGC catalysis, offering potential strategies for targeting haemostatic and non-haemostatic disorders associated with defects in γ-carboxylation.

Qing Cao
Aaron Ammerman
Weikai Li
Research29 Jan 2025
Nature

Volume: 639, P: 816-824
Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

Jingjing Li
Yajuan Xu
Wentao Wang
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Discovery of a chemical probe targeting the PWWP domain of NSD2 reveals insight into mechanisms that govern NSD2 localization. The compound and its negative control represent valuable tools for further defining NSD2 biology.

David Dilworth
Ronan P. Hanley
Matthieu Schapira
Research15 Nov 2021
Nature Chemical Biology

Volume: 18, P: 56-63
Single-DNA electron spin resonance spectroscopy in aqueous solutions

Single DNA molecules can be detected in aqueous solutions at ambient temperatures by electron spin resonance spectroscopy with diamond sensors.

Fazhan Shi
Fei Kong
Jiangfeng Du
Research06 Aug 2018
Nature Methods

Volume: 15, P: 697-699
Physisorption-assistant optoelectronic synaptic transistors based on Ta₂NiSe₅/SnS₂ heterojunction from ultraviolet to near-infrared

Fan Tan
Chunlu Chang
Shaojuan Li
ResearchOpen Access17 Mar 2025
Light: Science & Applications

Volume: 14, P: 1-12

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BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion

Molecular basis of vitamin-K-driven γ-carboxylation at the membrane interface

Differential lipids in pregnant women with subclinical hypothyroidism and their correlation to the pregnancy outcomes

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Single-DNA electron spin resonance spectroscopy in aqueous solutions

Physisorption-assistant optoelectronic synaptic transistors based on Ta2NiSe5/SnS2 heterojunction from ultraviolet to near-infrared

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BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4⁺ T-cell exhaustion

Physisorption-assistant optoelectronic synaptic transistors based on Ta₂NiSe₅/SnS₂ heterojunction from ultraviolet to near-infrared