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Showing 1–3 of 3 results
Advanced filters: Author: Mercè Jardí Clear advanced filters

  • García-Prat, Perdiguero, Alonso-Martín et al. show that skeletal muscle contains a subpopulation of quiescent stem cells, maintained by FoxO signalling, that is preserved into late life but declines in advanced geriatric age.

    • Laura García-Prat
    • Eusebio Perdiguero
    • Pura Muñoz-Cánoves
    Research
    Nature Cell Biology
    Volume: 22, P: 1307-1318

  • Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and protein degradation.

    • Jessica Segalés
    • Eusebio Perdiguero
    • Pura Muñoz-Cánoves
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16INK4a is identified as a common feature of senescent satellite cells.

    • Pedro Sousa-Victor
    • Susana Gutarra
    • Pura Muñoz-Cánoves
    Research
    Nature
    Volume: 506, P: 316-321