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Showing 1–6 of 6 results
Advanced filters: Author: Meriem Garfa-Traore Clear advanced filters

  • Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to protect centrioles against the shear stress generated by ciliary motility.

    • Alexia Mahuzier
    • Asm Shihavuddin
    • Nathalie Delgehyr
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Nephrophthisis (NPH) is a common manifestation of ciliopathy diseases. Here the authors identify mutations in intraflagellar transport 54 (IFT54) in patients with NPH and discover an extra-ciliary role for IFT54 in regulating cytoplasmic microtubule dynamics, that contributes to the pathophysiology of this disease.

    • Albane A. Bizet
    • Anita Becker-Heck
    • Sophie Saunier
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • STIM proteins sense Ca2+ depletion in the ER and activate store-operated Ca2+ entry in response, a process associated with dendritic cell (DC) functions. Here, the authors show that optimal antigen cross-presentation in DCs requires the association of the chaperone molecule UNC93B1 with STIM1.

    • Sophia Maschalidi
    • Paula Nunes-Hasler
    • Bénédicte Manoury
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • The receptor TLR9 needs to be carefully regulated to avoid recognition of self nucleic acids and ensuing autoinflammation. Saveanu and colleagues demonstrate a further level of regulation through the retention of TLR9 in IRAP+ endosomes.

    • Joel Babdor
    • Delphyne Descamps
    • Loredana Saveanu
    Research
    Nature Immunology
    Volume: 18, P: 509-518