Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Meru J. Sadhu Clear advanced filters

  • The authors present a CRISPR-library-based approach for highly efficient and precise genome-wide variant engineering. They examine the functional consequences of premature termination codons within all annotated essential genes in yeast.

    • Meru J. Sadhu
    • Joshua S. Bloom
    • Leonid Kruglyak
    Research
    Nature Genetics
    Volume: 50, P: 510-514

  • This study uses a large number of crosses between a common lab strain and vineyard-isolated strain of yeast, and estimates the phenotypic variance for various quantitative traits. Using this data set, the authors show additive quantitative trait loci (QTL) and QTL–QTL interactions to be on average 43% and 9%, respectively.

    • Joshua S. Bloom
    • Iulia Kotenko
    • Leonid Kruglyak
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6

  • Örjan Carlborg and colleagues analyze genotype and phenotype data from 4,390 yeast segregants from a cross between laboratory and vineyard strains to estimate how higher-order genetic interactions contribute to complex trait variation. They find networks of epistatic loci and show that accounting for these interactions leads to more accurate phenotypic predictions.

    • Simon K G Forsberg
    • Joshua S Bloom
    • Örjan Carlborg
    Research
    Nature Genetics
    Volume: 49, P: 497-503