Acidosis can stop seizures, but it is unclear how it does this. This study demonstrates that the acid-sensing channel ASIC1a is required for either spontaneous or CO2-induced termination of convulsant-induced seizures in mice. Moreover, ASIC1a strongly activates inhibitory interneurons under acidotic conditions, which may explain the effect.
- Adam E Ziemann
- Mikael K Schnizler
- John A Wemmie
