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Showing 1–16 of 16 results
Advanced filters: Author: Meshal Ansari Clear advanced filters

  • Here the authors map mesothelial cells across organs, revealing conserved disease-driven states. They identify key genes controlling the shift toward fibrosis and shows that blocking this reprogramming protects lungs, opening new anti-fibrosis strategies.

    • Safwen Kadri
    • Adrian Fischer
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • High resolution characterisation of the virus specific T cell response to SARS CoV2 provides further understanding to the immune response to the infection. Here the authors apply a reverse phenotyping approach to interrogate the SARS-CoV-2 T cell compartment at single cell resolution.”

    • David S. Fischer
    • Meshal Ansari
    • Kilian Schober
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

    • Gizem Günes Günsel
    • Thomas M. Conlon
    • Ali Önder Yildirim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Spatiotemporal regulation of wound healing in mice and humans occurs via retinoic acid and hypoxia signalling, which regulate the differentiation of CD201+ fibroblast progenitors into proinflammatory and myofibroblast states.

    • Donovan Correa-Gallegos
    • Haifeng Ye
    • Yuval Rinkevich
    ResearchOpen Access
    Nature
    Volume: 623, P: 792-802

  • Adipocyte plasticity during injury repair is debated. Here, the authors find that injury causes temporary adipocyte migration, but without lineage conversion to myofibroblasts. Distinct migration patterns, transcriptomics and ECM depositions indicate that adipocytes, unlike fibroblasts, do not contribute to fibrotic scars.

    • Shruthi Kalgudde Gopal
    • Ruoxuan Dai
    • Yuval Rinkevich
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.

    • Barbara Spix
    • Elisabeth S. Butz
    • Christian Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • CellRank infers directed cell state transitions and cell fates incorporating RNA velocity information into a graph based Markov process.

    • Marius Lange
    • Volker Bergen
    • Fabian J. Theis
    ResearchOpen Access
    Nature Methods
    Volume: 19, P: 159-170

  • Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict the cellular sources of regulated proteins.

    • Ilias Angelidis
    • Lukas M. Simon
    • Herbert B. Schiller
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.

    • Maximilian Strunz
    • Lukas M. Simon
    • Herbert B. Schiller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577

  • Practitioners in the field of single-cell omics are now faced with diverse options for analytical tools to process and integrate data from various molecular modalities. In an Expert Recommendation article, the authors provide guidance on robust single-cell data analysis, including choices of best-performing tools from benchmarking studies.

    • Lukas Heumos
    • Anna C. Schaar
    • Fabian J. Theis
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 550-572