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Showing 1–2 of 2 results
Advanced filters: Author: Micha Nethe Clear advanced filters

  • E-cadherin is a well-known tumor suppressor albeit loss of E-cadherin alone is insufficient to induce mammary tumorigenesis. Here the authors report that epithelial cells that have lost E-cadherin can survive by extruding to the basal lamina but require rebalancing of actomyosin contractility to drive tumor development.

    • Koen Schipper
    • Danielle Seinstra
    • Jos Jonkers
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Jos Jonkers, Lodewyk Wessels and colleagues use a Sleeping Beauty transposon mutagenesis screen to identify genes required for invasive lobular breast carcinoma formation (ILC) in mice. They find recurrent and mutually exclusive insertions in Myh9, Ppp1r12a, Ppp1r12b and Trp53bp2, which are implicated in the actin cytoskeleton regulation pathway and have been found to be altered in human ILC breast cancer.

    • Sjors M Kas
    • Julian R de Ruiter
    • Jos Jonkers
    Research
    Nature Genetics
    Volume: 49, P: 1219-1230