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Showing 1–5 of 5 results
Advanced filters: Author: Michael A. DeTure Clear advanced filters

  • Evidence suggests that fibrous aggregates of protein tau may be the proximal cause of Alzheimer’s disease. Here, using atomic structures of tau fibrils from brains of people with Alzheimer’s disease, the authors have found small-molecule drug leads that disaggregate tau fibrils in vitro.

    • Paul M. Seidler
    • Kevin A. Murray
    • David S. Eisenberg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Amyloid fibrils extracted from brains of patients with frontotemporal lobar degeneration with TAR DNA-binding-protein immunoreactivity (FTLD-TDP) are made up of transmembrane protein 106B.

    • Yi Xiao Jiang
    • Qin Cao
    • David S. Eisenberg
    Research
    Nature
    Volume: 605, P: 304-309

  • Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome of multiple etiologies which affects spoken communication. Here, the authors characterized the molecular pathology, biochemistry, genetics and longitudinal neuroimaging of 32 autopsy-confirmed patients with PAOS who were followed over 10 years.

    • Keith A. Josephs
    • Joseph R. Duffy
    • Jennifer L. Whitwell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Alzheimer’s disease (AD) is typically associated with hippocampal and cortical pathology, although hippocampal sparing and limbic predominant forms exist. The authors use transcriptomic analysis and neuropathology to identify genes associated with selective hippocampal vulnerability in AD.

    • Angela M. Crist
    • Kelly M. Hinkle
    • Melissa E. Murray
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Evidence suggests that aberrant RNA processing contributes to amyotrophic lateral sclerosis (ALS). Using RNA sequencing, Prudencio et al. assessed the extent of transcriptome defects in C9orf72-associated (c9ALS) and sporadic ALS (sALS) brains. They report extensive defects in expression, alternative splicing and alternative polyadenylation that are significantly distinct between individuals with c9ALS and sALS.

    • Mercedes Prudencio
    • Veronique V Belzil
    • Leonard Petrucelli
    Research
    Nature Neuroscience
    Volume: 18, P: 1175-1182