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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

The nucleoporin RanBP2 functions in cellular transport, mitosis and SUMO conjugation. Here, the authors determine cryo-EM structures of RanBP2 complexed with SUMO1-RanGAP1, Ubc9, Crm1, Ran and use cell and biochemical assays to probe its functions.

Vladimir Baytshtok
Michael A. DiMattia
Christopher D. Lima
ResearchOpen Access11 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Mark W. Sornson
Wei Wu
Michael G. Rosenfeld
Research28 Nov 1996
Nature

Volume: 384, P: 327-333
Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

Sheng-Cai Lin
Chijen R. Lin
Michael G. Rosenfeld
Research15 Jul 1993
Nature

Volume: 364, P: 208-213
E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

Martin Oeggerli
Sanja Tomovska
Guido Sauter
Research03 May 2004
Oncogene

Volume: 23, P: 5616-5623
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

Scott Canna and colleagues report the identification of a de novo mutation in a conserved region of NLRC4 by whole-exome sequencing of an individual presenting with macrophage activation syndrome. Functional studies confirm that the mutation leads to constitutive inflammasome activation.

Scott W Canna
Adriana A de Jesus
Raphaela Goldbach-Mansky
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1140-1146

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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

Search

Quick links