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Showing 1–8 of 8 results
Advanced filters: Author: Michael A. Geeves Clear advanced filters

  • Myosin motors perform many fundamental functions in eukaryotic cells by providing force generation, transport or tethering capacity. Here, the authors show that a single phosphorylation event can modulate actin-activated ATPase activity and change the mechanical properties of myosin-VI.

    • Janeska J. de Jonge
    • Andreas Graw
    • Folma Buss
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Myosin, a motor protein essential for intracellular transport to muscle contraction, requires a chaperone UNC-45 for folding and assembly. Here authors use in vitro reconstitution and structural biology to characterize the interplay between UNC-45 and muscle myosin MHC-B.

    • Doris Hellerschmied
    • Anita Lehner
    • Tim Clausen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Motor proteins are essential to life: without them, all cellular transport would grind to a halt. New results on the size of steps taken by one family of motors, the myosins, will fuel the debate about how they move.

    • Michael A. Geeves
    News & Views
    Nature
    Volume: 415, P: 129-131

  • The use of abbreviated pathway constructs leads to trapping of a series of cobalamin intermediates, allowing assignment of the full biosynthetic pathway and defining the roles of CobL as a dual-function methyltransferase and CobE as a likely carrier protein, perhaps facilitating metabolic channeling.

    • Evelyne Deery
    • Susanne Schroeder
    • Martin J Warren
    Research
    Nature Chemical Biology
    Volume: 8, P: 933-940

  • The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation is located near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here the authors assessed M305L actin in vivo, in vitro, and in silico to characterize emergent pathological properties and define the mechanistic basis of disease.

    • Meera C. Viswanathan
    • William Schmidt
    • Anthony Cammarato
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • This protocol describes the design, in vitro characterization, and imaging applications of iGluSnFR-based genetically encoded glutamate indicators (GEGIs) in tissue culture of rat hippocampus.

    • Céline D. Dürst
    • J. Simon Wiegert
    • Thomas G. Oertner
    Protocols
    Nature Protocols
    Volume: 14, P: 1401-1424