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Showing 1–4 of 4 results
Advanced filters: Author: Michael A. Koldobskiy Clear advanced filters

  • hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mouse retina than conventional PSCs.

    • Tea Soon Park
    • Ludovic Zimmerlin
    • Elias T. Zambidis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • Disruption to the epigenome is increasingly appreciated as a major contributor to the development of cancer. The authors discuss how conceptualizing genes affecting the epigenome as epigenetic modulators, epigenetic modifiers or epigenetic mediators provides a valuable framework for understanding diverse aspects of the causes and consequences of epigenome alteration in cancer.

    • Andrew P. Feinberg
    • Michael A. Koldobskiy
    • Anita Göndör
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 284-299

  • The activity of myriad nuclear proteins is regulated by S-nitrosylation, but a nuclear nitrosylase has remained elusive. GAPDH is now shown to be nitrosylated in the cytoplasm, which promotes its import into the nucleus, where it then transnitrosylates nuclear proteins.

    • Michael D. Kornberg
    • Nilkantha Sen
    • Solomon H. Snyder
    Research
    Nature Cell Biology
    Volume: 12, P: 1094-1100