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Showing 1–11 of 11 results
Advanced filters: Author: Michael Axtell Clear advanced filters

  • The authors show that gaseous Nitric Oxide (NO) promotes transit amplifying cell fate in the Arabidopsis shoot meristem. NO acts by modifying AGO4-WUSCHEL protein interactions in stem cells, directly linking NO signaling with DNA methylation.

    • Jian Zeng
    • Xin’Ai Zhao
    • Jan U. Lohmann
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The meiotic transmissibility and progeny phenotypic influence of graft-mediated epigenetic changes remain unclear. Here, the authors use the msh1 mutant in the rootstock to trigger heritable enhanced growth vigor in Arabidopsis and tomato, and show it is associated with the RNA-directed DNA methylation pathway.

    • Hardik Kundariya
    • Xiaodong Yang
    • Sally A. Mackenzie
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Segregation of an MSH1 RNAi transgene produces non-genetic memory that displays transgenerational inheritance in Arabidopsis. Here, the authors compare memory and non-memory full-sib progenies to show the involvement of DNA methylation reprogramming, involving the RdDM pathway, in transition to a heritable memory state.

    • Xiaodong Yang
    • Robersy Sanchez
    • Sally A. Mackenzie
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Xavier Argout and colleagues report the draft genome of Theobroma cacao, the tropical crop that is the source of chocolate. The sequence assembly covers approximately 80% of the genome.

    • Xavier Argout
    • Jerome Salse
    • Claire Lanaud
    ResearchOpen Access
    Nature Genetics
    Volume: 43, P: 101-108

  • Cells associated with the male germlines of grasses produce huge amounts of small RNAs. A large survey of two types of small RNA in maize uncovers unique characteristics associated with male fertility, but the molecular mechanism by which these germline-associated small RNAs function remains unclear.

    • Michael J. Axtell
    News & Views
    Nature Plants
    Volume: 1, P: 1-2

  • S1P1 is a sphingosine phosphate receptor expressed on lymphocytes. Han and colleagues show that phosphorylated S1P1 accumulates in brain lesions of patients with multiple sclerosis. Similarly, mice bearing mutant S1P1 develop more severe experimental autoimmune encephalomyelitis.

    • Christopher S Garris
    • Linfeng Wu
    • May H Han
    Research
    Nature Immunology
    Volume: 14, P: 1166-1172

  • How plant pri-miRNAs with complex secondary structures are recognized and processed has been unclear. A new study now suggests that unlike canonical processing of pri-miRNAs, terminal loop–branched pri-miRNAs can be processed by Dicer-like 1 (DCL1) complexes bidirectionally, either from the lower stem to the terminal loop or vice versa, resulting in productive and abortive processing of miRNAs, respectively.

    • Hongliang Zhu
    • Yuyi Zhou
    • Xiuren Zhang
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1106-1115

  • The field of biological cardiac pacing, which aims to improve upon, supplement and, eventually, to replace electronic pacing has come a long way since its inception more than a decade ago. Broadly, research has been focused on gene and cell therapy. In this Review, Rosen and colleagues highlight milestones achieved through the construction of a 'roadmap' in biological pacing, and discuss the barriers that remain to be overcome before clinical trials of biological pacing can be begun.

    • Michael R. Rosen
    • Richard B. Robinson
    • Ira S. Cohen
    Reviews
    Nature Reviews Cardiology
    Volume: 8, P: 656-666