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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling.

Ling Huang
Audrey Holtzinger
Senthil K Muthuswamy
Research26 Oct 2015
Nature Medicine

Volume: 21, P: 1364-1371
An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

Muthuswamy et al. report that in macrophages SCRIB interacts with the NADPH oxidase complex to promote the production of reactive oxygen species needed to kill bacteria. Conversely, loss of SCRIB promotes M1 macrophage polarization and inflammation.

Weiyue Zheng
Masataka Umitsu
Senthil K. Muthuswamy
Research03 Oct 2016
Nature Cell Biology

Volume: 18, P: 1244-1252
Patient-derived tumor xenograft and organoid models established from resected pancreatic, duodenal and biliary cancers

Nhu-An Pham
Nikolina Radulovich
Ming-Sound Tsao
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-12