Nature Search

Higher mortality following SARS-CoV-2 infection in rural versus urban dwellers persists for two years post-infection

People living in rural areas of the United States have poorer outcomes from acute COVID-19. Here, the authors show that higher mortality rates among rural dwellers persist for up to two years after the initial infection, even after accounting for baseline risk factors.

A. Jerrod Anzalone
Michael T. Vest
Christopher G. Chute
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-18
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for preventing polyposis in patients with HMPS.

Eoghan J. Mulholland
Hayley L. Belnoue-Davis
Simon J. Leedham
ResearchOpen Access04 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Benefits for children with suspected cancer from routine whole-genome sequencing

In a cohort of 281 children with diagnosed or suspected cancer presenting to the NHS, implementing routine whole-genome sequencing provided clinical benefit in 29% of cases and led to change in management in 7% of patients.

Angus Hodder
Sarah M. Leiter
Sam Behjati
ResearchOpen Access02 Jul 2024
Nature Medicine

Volume: 30, P: 1905-1912
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Effects on lower trophic levels of massive fish mortality

Michael J. Vanni
Chris Luecke
John J. Magnuson
Research22 Mar 1990
Nature

Volume: 344, P: 333-335
Short-latency drinking and increased Na appetite after intracerebral microinjections of NGF in rats

MICHAEL E. LEWIS
DOUGLAS B. AVRITH
JAMES T. FITZSIMONS
Research01 May 1979
Nature

Volume: 279, P: 440-442
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Benjamin S. Haslund-Gourley
Kyra Woloszczuk
Mary Ann Comunale
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

NOTUM from Apc-mutant cells acts as a key mediator during the early stages of mutation fixation and drives the formation of intestinal adenomas.

Dustin J. Flanagan
Nalle Pentinmikko
Owen J. Sansom
Research02 Jun 2021
Nature

Volume: 594, P: 430-435
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.

David M. Gay
Rachel A. Ridgway
Owen J. Sansom
ResearchOpen Access13 Feb 2019
Nature Communications

Volume: 10, P: 1-16
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.

Joshua D. G. Leach
Nikola Vlahov
Owen J. Sansom
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

David M. Gay
Rachel A. Ridgway
Owen J. Sansom
Amendments and CorrectionsOpen Access26 Mar 2019
Nature Communications

Volume: 10, P: 1
985 ONTOGENY OF B CELL FUNCTION IN HUMAN BONE MARROW

Toshifumi Hibi
Marcia A Chan
Hans-Michael Dosch
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 275
PLATELET COUNT AND PLATELET-ASSOCIATED IgG IN 123 CONSECUTIVE PREGNANCIES: RELATIONSHIP MATERNAL ACTORS TO NE NATAL PLATELET COUNT

David Hart
Michael Nardi
Margaret Karpatkin
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 241
The history of modern spinal traction with particular reference to neural disorders

Michael V Shterenshis
Research01 Mar 1997
Spinal Cord

Volume: 35, P: 139-146
Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

Romina J. Walter
Steffen J. Sonnentag
Véronique Orian-Rousseau
ResearchOpen Access21 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-16
The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure

Hasan M. Al-Dorzi
Abdulaziz Al-Dawood
Yaseen M. Arabi
ResearchOpen Access20 May 2022
Scientific Reports

Volume: 12, P: 1-10
TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

Patrizia Cammareri
David F Vincent
Owen J Sansom
ResearchOpen Access16 Jun 2017
Cell Death & Differentiation

Volume: 24, P: 1681-1693
A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

Samuel Challéat
Nicolas Farrugia
Vera Zina
ResearchOpen Access27 Aug 2024
Scientific Data

Volume: 11, P: 1-16

Search

Higher mortality following SARS-CoV-2 infection in rural versus urban dwellers persists for two years post-infection

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

Benefits for children with suspected cancer from routine whole-genome sequencing

Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Effects on lower trophic levels of massive fish mortality

Short-latency drinking and increased Na appetite after intracerebral microinjections of NGF in rats

IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

985 ONTOGENY OF B CELL FUNCTION IN HUMAN BONE MARROW

PLATELET COUNT AND PLATELET-ASSOCIATED IgG IN 123 CONSECUTIVE PREGNANCIES: RELATIONSHIP MATERNAL ACTORS TO NE NATAL PLATELET COUNT

The history of modern spinal traction with particular reference to neural disorders

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

The effect of intermittent pneumatic compression on deep-vein thrombosis and ventilation-free days in critically ill patients with heart failure

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

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