As part of the response to exogenous DNA damage, the transcription of certain genes involved in cell cycle checkpoints and survival is affected; these changes help the cell to maintain its genomic integrity. There are also situations in which endogenous, physiological DNA double-strand breaks occur. This paper shows that the breaks which initiate the rearrangement of antigen receptor genes also activate a transcriptional program, but with a difference. Many of the regulated genes are involved in lymphocyte development.
- Andrea L. Bredemeyer
- Beth A. Helmink
- Barry P. Sleckman
