In this study, Mazzoni et al. describe the mechanism behind the combinatorial action of transcription factors in cell type specification. Specifically, the authors reveal that Isl1 cooperates with Phox2a or Lhx3 in programming modules that regulate differential specification of spinal motor neurons vs. cranial motor neurons.
- Esteban O Mazzoni
- Shaun Mahony
- Hynek Wichterle
