Nature Search

Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Spleen cells from Schistosoma mansoni-infected mice produce diffusible stimulator of eosinophilopoiesis in vivo

ALAN M. MILLER
DANIEL G. COLLEY
MICHAEL P. MCGARRY
Research12 Aug 1976
Nature

Volume: 262, P: 586-587
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Next-generation characterization of the Cancer Cell Line Encyclopedia

The original Cancer Cell Line Encyclopedia (CCLE) is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data.

Mahmoud Ghandi
Franklin W. Huang
William R. Sellers
Research08 May 2019
Nature

Volume: 569, P: 503-508
Westward expansion

Michael Eisenstein
Protocols01 Oct 2005
Nature Methods

Volume: 2, P: 796
FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

Tingxiang Yan
Jingjing Liang
Xinglong Wang
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.

Pratiti Bandopadhayay
Federica Piccioni
Rameen Beroukhim
ResearchOpen Access03 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Liang-Yu Huang
Chen-Chen Tan
Dariella Fernandez
ResearchOpen Access08 Jul 2025
Translational Psychiatry

Volume: 15, P: 1-11
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Tingxiang Yan
Jingjing Liang
Xinglong Wang
Amendments and CorrectionsOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-2
Integration of biological networks and gene expression data using Cytoscape

Melissa S Cline
Michael Smoot
Gary D Bader
Protocols27 Sept 2007
Nature Protocols

Volume: 2, P: 2366-2382
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Donghuan Lu
Karteek Popuri
Kristin Fargher
ResearchOpen Access09 Apr 2018
Scientific Reports

Volume: 8, P: 1-13
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Ines Mahjoub
Mohamed Ali Mahjoub
Kristin Fargher
ResearchOpen Access07 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Xinpeng Shen
Sisi Ma
Kristin Fargher
ResearchOpen Access19 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

Emrin Horgusluoglu-Moloch
Shannon L. Risacher
Kristin Fargher
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Meiyan Huang
Wei Yang
Kristin Fargher
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Lei Du
Kefei Liu
Kristin Fargher
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-14
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Shi-Dong Chen
Jia-Ying Lu
Michelle Zmuda
ResearchOpen Access18 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-12
Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Xue-Ning Shen
Yu-Yuan Huang
Michelle Zmuda
ResearchOpen Access13 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Azevedo et al. conduct a machine learning-based analysis of structural MRI data from multiple cohorts. The authors identify Alzheimer’s disease-like neuroimaging phenotypes associated with poorer cognitive performance in a healthy UK Biobank cohort, potentially highlighting a population at risk of Alzheimer’s disease.

Tiago Azevedo
Richard A. I. Bethlehem
Gail Li
ResearchOpen Access20 Jul 2023
Communications Medicine

Volume: 3, P: 1-15
Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Yeonwoo Chung
Hyunju Lee
Kristin Fargher
ResearchOpen Access27 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
ResearchOpen Access25 Sept 2019
Scientific Reports

Volume: 9, P: 1-16
Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Margherita Squillario
Giulia Abate
Kristin Fargher
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

Yogatheesan Varatharajah
Vijay K. Ramanan
Kristin Fargher
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-15
A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

Haochen Liu
Xiaoting Zhou
Kristin Fargher
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Benjamin Goudey
Bowen J. Fung
Brenda Plassman
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Yuetiva Deming
Jian Xia
Carlos Cruchaga
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-17
Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Lin Tan
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-12
Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease

Xiaoke Hao
Chanxiu Li
Kristin Fargher
ResearchOpen Access14 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Wei Xu
Hui-Fu Wang
Kristin Fargher
ResearchOpen Access27 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Asha Singanamalli
Haibo Wang
Kristin Fargher
ResearchOpen Access15 Aug 2017
Scientific Reports

Volume: 7, P: 1-14
Author Correction: Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Garam Lee
Kwangsik Nho
Kristin Fargher
Amendments and CorrectionsOpen Access01 Aug 2023
Scientific Reports

Volume: 13, P: 1
Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification

Kilian Hett
Vinh-Thong Ta
Kristin Fargher
Amendments and CorrectionsOpen Access30 Jun 2020
Scientific Reports

Volume: 10, P: 1

Search

Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Spleen cells from Schistosoma mansoni-infected mice produce diffusible stimulator of eosinophilopoiesis in vivo

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Next-generation characterization of the Cancer Cell Line Encyclopedia

Westward expansion

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

Integration of biological networks and gene expression data using Cytoscape

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways

A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study

Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status

Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank

Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Predicting Alzheimer’s disease progression using multi-modal deep learning approach

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics

A semi-mechanism approach based on MRI and proteomics for prediction of conversion from mild cognitive impairment to Alzheimer’s disease

A blood-based signature of cerebrospinal fluid Aβ_1–42 status

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features

Author Correction: Predicting Alzheimer’s disease progression using multi-modal deep learning approach

Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification

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