Nature Search

Mesozoic ophiolite and blue amphibole on Timor and the dispersal of eastern Gondwanaland

Michael M. Earle
Research22 Nov 1979
Nature

Volume: 282, P: 375-378
A cell-surface molecule involved in organ-specific homing of lymphocytes

W. Michael Gallatin
Irving L. Weissman
Eugene C. Butcher
Research01 Jul 1983
Nature

Volume: 304, P: 30-34
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Here, DNA damage is shown to occur as a direct consequence of inducing haematopoietic stem cells to exit quiescence in response to conditions of stress; in mice with mutations modelling those seen in Fanconi anaemia, this leads to a complete collapse of the haematopoietic system.

Dagmar Walter
Amelie Lier
Michael D. Milsom
Research18 Feb 2015
Nature

Volume: 520, P: 549-552
Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Saçma, Pospiech and co-workers show that sinusoidal niches are uniquely preserved on ageing, that they are the predominant niche for label-retaining (LR)-HSCs in aged mice and display higher reconstitution capacity compared with non-LR HSCs.

Mehmet Saçma
Johannes Pospiech
Maria Carolina Florian
Research04 Nov 2019
Nature Cell Biology

Volume: 21, P: 1309-1320
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Human and mouse cells expressing a redox-insensitive GAPDH mutant that otherwise retains its catalytic activity are shown to be unable to upregulate the oxidative pentose phosphate pathway in response to oxidative stress.

Deepti Talwar
Colin G. Miller
Tobias P. Dick
ResearchOpen Access06 Apr 2023
Nature Metabolism

Volume: 5, P: 660-676
Somatic mutation rates scale with lifespan across mammals

Whole-genome sequencing is used to analyse the landscape of somatic mutation in intestinal crypts from 16 mammalian species, revealing that rates of somatic mutation inversely scale with the lifespan of the animal across species.

Alex Cagan
Adrian Baez-Ortega
Iñigo Martincorena
ResearchOpen Access13 Apr 2022
Nature

Volume: 604, P: 517-524
Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Müller-Tidow and colleagues demonstrate that hotspot DNMT3A mutations found in clonal hematopoiesis and acute myeloid leukemia render cancer cells sensitive to the DNMT1 inhibitor azacitidine through focal DNA demethylation, viral mimicry and interferon activation.

Marina Scheller
Anne Kathrin Ludwig
Carsten Müller-Tidow
Research25 May 2021
Nature Cancer

Volume: 2, P: 527-544
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Blockade of intrahepatic accumulation and function of platelets represents a potential approach to treat non-alcoholic steatohepatitis (NASH) and prevent subsequent progression to hepatocellular carcinoma

Mohsen Malehmir
Dominik Pfister
Mathias Heikenwalder
Research01 Apr 2019
Nature Medicine

Volume: 25, P: 641-655
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

A blood enhancer cluster forms a highly combinatorial system that allows precise control of Myc expression across normal and leukaemic haematopoietic stem-cell hierarchies.

Carsten Bahr
Lisa von Paleske
François Spitz
Research17 Jan 2018
Nature

Volume: 553, P: 515-520
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.

Xuan Sun
Benjamin Cao
Susan K. Nilsson
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-17
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Mohsen Malehmir
Dominik Pfister
Mathias Heikenwalder
Amendments and Corrections18 Feb 2022
Nature Medicine

Volume: 28, P: 600
Bridging the information gap

The interaction between hematopoietic stem cells and their niche is critical for the lifelong maintenance of the blood system. New research shows that crosstalk between stromal components of the niche mediates secretion of the chemokine CXCL12.

Michael D Milsom
Andreas Trumpp
News & Views19 Apr 2011
Nature Immunology

Volume: 12, P: 377-379
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

New xenograft models of colorectal cancer exhibit metastasis to the liver, use immunocompetent mice and show improved resistance to chemotherapy.

Huanhuan Joyce Chen
Jian Sun
Steven M Lipkin
Research25 May 2015
Nature Biotechnology

Volume: 33, P: 656-660
Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Rebecca J. Austin
Jasmin Straube
Steven W. Lane
Research15 Nov 2019
Leukemia

Volume: 34, P: 1075-1089
Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes

M Rothe
I Rittelmeyer
U Modlich
Research18 Aug 2011
Gene Therapy

Volume: 19, P: 425-434

Search

Mesozoic ophiolite and blue amphibole on Timor and the dispersal of eastern Gondwanaland

A cell-surface molecule involved in organ-specific homing of lymphocytes

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells

Somatic mutation rates scale with lifespan across mammals

Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Bridging the information gap

Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes

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