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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

The nuclear receptors REV-ERB-α and REV-ERB-β are indispensible for the coordination of circadian rhythm and metabolism; mice without these nuclear receptors show disrupted circadian expression of core circadian clock and lipid homeostatic gene networks.

Han Cho
Xuan Zhao
Ronald M. Evans
Research29 Mar 2012
Nature

Volume: 485, P: 123-127
Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface

Michael J. Hayman
Hartmut Beug
Research31 May 1984
Nature

Volume: 309, P: 460-462
Domain structure of human glucocorticoid receptor and its relationship to the v-erb-A oncogene product

Cary Weinberger
Stanley M. Hollenberg
Ronald M. Evans
Research19 Dec 1985
Nature

Volume: 318, P: 670-672
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Synthetic REV-ERB agonists can alter the circadian expression of core clock genes in the hypothalami of mice, which changes the expression of metabolic genes in liver, skeletal muscle and adipose tissue, and results in increased energy expenditure.

Laura A. Solt
Yongjun Wang
Thomas P. Burris
Research29 Mar 2012
Nature

Volume: 485, P: 62-68
A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

Christopher K. Glass
Rodrigo Franco
Michael G. Rosenfeld
Research22 Oct 1987
Nature

Volume: 329, P: 738-741
Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells

Nadeen Anabtawi
William Cvammen
Michael G. Kemp
ResearchOpen Access09 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, the repressive functions of Rev-Erb nuclear receptors in macrophages are shown to be linked to their ability to inhibit the transcription of eRNAs.

Michael T. Y. Lam
Han Cho
Christopher K. Glass
Research02 Jun 2013
Nature

Volume: 498, P: 511-515
The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

Xiaodong Zhuang
Andrea Magri
Jane A. McKeating
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-13
Domesticated cannabinoid synthases amid a wild mosaic cannabis pangenome

A pangenome of the Cannabis genus including 193 genomes demonstrates high variability in most of the genome but low diversity in cannabinoid synthesis genes and provides a resource for future genetic studies and crop optimization.

Ryan C. Lynch
Lillian K. Padgitt-Cobb
Todd P. Michael
ResearchOpen Access28 May 2025
Nature

Volume: 643, P: 1001-1010
The role of REV-ERB in NASH

Kristine Griffett
Matthew E. Hayes
Thomas P. Burris
Reviews25 Feb 2022
Acta Pharmacologica Sinica

Volume: 43, P: 1133-1140
Steroid receptors: Oncogenes as hormone receptors

J. Michael Bishop
News & Views08 May 1986
Nature

Volume: 321, P: 112-113
Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes

Mark Rabin
Charles P. Hart
Frank H. Ruddle
Research14 Mar 1985
Nature

Volume: 314, P: 175-178
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

Michael E. Greenberg
Edward B. Ziff
Research04 Oct 1984
Nature

Volume: 311, P: 433-438
Molecular portraits of human breast tumours

Charles M. Perou
Therese Sørlie
David Botstein
Research17 Aug 2000
Nature

Volume: 406, P: 747-752
Outracing champion Gran Turismo drivers with deep reinforcement learning

Using the game Gran Turismo, an agent was trained with a combination of deep reinforcement learning algorithms and specialized training scenarios, demonstrating success against championship-level human racers.

Peter R. Wurman
Samuel Barrett
Hiroaki Kitano
Research09 Feb 2022
Nature

Volume: 602, P: 223-228
Prolonged and tunable residence time using reversible covalent kinase inhibitors

Structural changes in the capping groups of inverted cyanoacrylamide-based kinase inhibitors resulted in alterations in residence time, with some compounds exhibiting sustained pharmacological effects in vivo.

J Michael Bradshaw
Jesse M McFarland
Jack Taunton
Research25 May 2015
Nature Chemical Biology

Volume: 11, P: 525-531
Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions

In this Roadmap, Aggarwal and colleagues summarize current research and knowledge gaps on the relationship between sleep, circadian rhythms and cardiovascular resilience; highlight potential therapeutic targets and interventions for optimizing sleep and circadian rhythms to improve cardiovascular function and prevent disease; and outline research directions and opportunities, emphasizing the need for multidisciplinary collaboration.

Brooke Aggarwal
Yunling Gao
Donald Lloyd-Jones
Reviews18 Sept 2025
Nature Reviews Cardiology

P: 1-15
Cosmology: Views with a gravitational lens

Rachel Webster
Michael Fitchett
News & Views18 Dec 1986
Nature

Volume: 324, P: 617-618
Identification of the remains of King Richard III

King Richard III was a controversial English King whose remains are presumably deposited in Grey Friars in Leicester. Here the authors sequence the mitochondrial genome and Y-chromosome DNA of the skeletal remains and living relatives of Richard III and confirm that the remains belong to King Richard III.

Turi E. King
Gloria Gonzalez Fortes
Kevin Schürer
ResearchOpen Access02 Dec 2014
Nature Communications

Volume: 5, P: 1-8
Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion

Wenjuan Xian
Michael P Rosenberg
John DiGiovanni
Research27 Mar 1997
Oncogene

Volume: 14, P: 1435-1444
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

Jean-Pierre Etchegaray
Choogon Lee
Steven M. Reppert
Research11 Dec 2002
Nature

Volume: 421, P: 177-182
The human met oncogene is related to the tyrosine kinase oncogenes

Michael Dean
Morag Park
George F. Vande Woude
Research28 Nov 1985
Nature

Volume: 318, P: 385-388
Insights into social insects from the genome of the honeybee Apis mellifera

George M. Weinstock
Gene E. Robinson
Rita Wright
Research26 Oct 2006
Nature

Volume: 443, P: 931-949
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

Towia A. Libermann
Harris R. Nusbaum
Joseph Schlessinger
Research10 Jan 1985
Nature

Volume: 313, P: 144-147
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

Mark D. Iafrati
Richard H. Karas
Michael E. Mendelsohn
Research01 May 1997
Nature Medicine

Volume: 3, P: 545-548
APOBEC3 mutagenesis drives therapy resistance in breast cancer

Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated with mutations known to drive drug resistance.

Avantika Gupta
Andrea Gazzo
Sarat Chandarlapaty
ResearchOpen Access16 May 2025
Nature Genetics

Volume: 57, P: 1452-1462
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

Manfred Schwab
Kari Alitalo
Donna George
Research01 Jun 1983
Nature

Volume: 303, P: 497-501
Generation of circadian rhythms in the suprachiasmatic nucleus

In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus acts as the principal pacemaker for circadian rhythms, which are powerful regulators of physiology and behaviour. In this Review, Hastings, Maywood and Brancaccio examine the molecular, cellular and circuit mechanisms underlying time-keeping in the SCN.

Michael H. Hastings
Elizabeth S. Maywood
Marco Brancaccio
Reviews22 Jun 2018
Nature Reviews Neuroscience

Volume: 19, P: 453-469
Using Ontology Fingerprints to Evaluate Genome-wide Association Results

Lam Tsoi
Michael Boehnke
Jim Zheng
ResearchOpen Access29 Jul 2009
Nature Precedings

P: 1
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Circadian co-regulators cryptochrome 1 and 2 are shown to alter globally the transcriptional response to glucocorticoids in mouse embryonic fibroblasts.

Katja A. Lamia
Stephanie J. Papp
Ronald M. Evans
Research14 Dec 2011
Nature

Volume: 480, P: 552-556
Cellular transformation by coordinated action of three peptide growth factors from human platelets

Richard K. Assoian
Gary R. Grotendorst
Michael B. Sporn
Research28 Jun 1984
Nature

Volume: 309, P: 804-806
Autocrine growth factors and cancer

Michael B. Sporn
Anita B. Roberts
Reviews28 Feb 1985
Nature

Volume: 313, P: 745-747
LZTR1 is a melanoma oncogene that promotes invasion and suppresses apoptosis

Antonella Bacchiocchi
Michael Mak
Ruth Halaban
ResearchOpen Access30 Aug 2025
Oncogene

Volume: 44, P: 3974-3984
A Cytolytic Parasite in the Cells of Transplantable, Malignant Tumours

MICHAEL PETRI
Research16 Jan 1965
Nature

Volume: 205, P: 302-303
Lycopodium spores found in condom dusting agent

MICHAEL J. BALICK
JOSEPH M. BEITEL
Research14 Apr 1988
Nature

Volume: 332, P: 591
A promiscuous mechanism to phase separate eukaryotic carbon fixation in the green lineage

Barrett et al. identify a key Rubisco phase-separating protein in the CO₂-fixing pyrenoid of Chlorella algae. This protein’s broad promiscuity for green lineage Rubiscos may aid in engineering CO₂-supercharging pyrenoids in plants to boost yields.

James Barrett
Mihris I. S. Naduthodi
Luke C. M. Mackinder
ResearchOpen Access09 Oct 2024
Nature Plants

Volume: 10, P: 1801-1813
Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

The type III secretion system effectors NleB and SseK are glycosyltransferases (GT) that specifically glycosylate arginine residues. Here the authors provide insights into their mechanism by combining X-ray crystallography, NMR, enzyme kinetics measurements, molecular dynamics simulations and in vivo experiments and show that SseK/NleB enzymes are retaining GTs.

Jun Bae Park
Young Hun Kim
Hyun-Soo Cho
ResearchOpen Access16 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Primary structure and expression of a functional human glucocorticoid receptor cDNA

Stanley M. Hollenberg
Cary Weinberger
Ronald M. Evans
Research19 Dec 1985
Nature

Volume: 318, P: 635-641
Recent ultra-rare inherited variants implicate new autism candidate risk genes

Analysis of whole-genome sequence data from 3,474 families finds an excess of private, likely gene-disrupting variants in individuals with autism. These variants are under purifying selection and suggest candidate genes not previously associated with autism.

Amy B. Wilfert
Tychele N. Turner
Evan E. Eichler
Research26 Jul 2021
Nature Genetics

Volume: 53, P: 1125-1134
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity

Reto Huber
M Felice Ghilardi
Giulio Tononi
Research27 Aug 2006
Nature Neuroscience

Volume: 9, P: 1169-1176
A gene expression database for the molecular pharmacology of cancer

Uwe Scherf
Douglas T. Ross
John N. Weinstein
Research01 Mar 2000
Nature Genetics

Volume: 24, P: 236-244
Molecular mechanisms and physiological importance of circadian rhythms

Animal circadian rhythms are controlled by central and peripheral molecular clocks, whose components generate oscillations in their own abundance and activity. Insights into how these clocks time the function of organs and tissues is increasing our understanding of animal physiology.

Alina Patke
Michael W. Young
Sofia Axelrod
Reviews25 Nov 2019
Nature Reviews Molecular Cell Biology

Volume: 21, P: 67-84
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Batlle and colleagues develop an organoid platform for functional antibody screening and identify a therapeutic bispecific antibody that binds EGFR and LGR5 and that shows efficacy across epithelial tumor patient-derived xenograft models in vivo.

Bram Herpers
Berina Eppink
Mark Throsby
Research25 Apr 2022
Nature Cancer

Volume: 3, P: 418-436
Social jetlag alters markers of exercise-induced mitochondrial adaptations in the heart

Michael B. Dial
Elias M. Malek
Graham R. McGinnis
ResearchOpen Access25 Jan 2025
npj Biological Timing and Sleep

Volume: 2, P: 1-9
Novel mutations of the MET proto-oncogene in papillary renal carcinomas

Laura Schmidt
Kerstin Junker
Berton Zbar
Research08 Apr 1999
Oncogene

Volume: 18, P: 2343-2350
Correspondence: Reply to ‘Oncogenic MYC persistently upregulates the molecular clock component REV-ERBα’

Anton Shostak
Bianca Ruppert
Michael Brunner
CorrespondenceOpen Access23 Mar 2017
Nature Communications

Volume: 8, P: 1-4
The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer

CDK4/6 inhibition is a promising therapeutic approach to treat cancer, but it is challenged by resistance development. Here, the authors show that the RNA binding protein LRPPRC forms a positive feedback loop with CDK6 and inhibiting LRPPRC with the FDA-approved gossypol acetate overcomes CDK4/6 inhibition resistance.

Wei Zhou
Wenxi Wang
Xiaohong Fang
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Molecular cloning of a new transforming gene from a chemically transformed human cell line

Colin S. Cooper
Morag Park
George F. Vande Woude
Research06 Sept 1984
Nature

Volume: 311, P: 29-33
DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex

A comprehensive HDX analysis of the vitamin D receptor–retinoid X receptor (VDR-RXR) reveals extensive allosteric communication within the same polypeptide where DNA or ligand can induce alterations in distant domains of the receptors. The work also shows communication between subunits in the heterodimer.

Jun Zhang
Michael J Chalmers
Patrick R Griffin
Research10 Apr 2011
Nature Structural & Molecular Biology

Volume: 18, P: 556-563
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis

In an interim analysis of a phase 1 trial, repeated intracranial infusions of HER2-specific CAR T cells were well tolerated with no observed dose-limiting toxicities in three young adult patients with CNS tumors.

Nicholas A. Vitanza
Adam J. Johnson
Julie R. Park
Research12 Jul 2021
Nature Medicine

Volume: 27, P: 1544-1552

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