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Advanced filters: Author: Michael F. Cuccarese Clear advanced filters

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.

Michael F. Cuccarese
J. Matthew Dubach
Ralph Weissleder
ResearchOpen Access08 Feb 2017
Nature Communications

Volume: 8, P: 1-10
Quantitating drug-target engagement in single cells in vitro and in vivo

The use of fluorescence-polarized microscopy, combined with competitive binding with matched fluorescence companion imaging probes, enable target engagement measurements of covalent and reversible small molecule inhibitors in a single cell.

J Matthew Dubach
Eunha Kim
Ralph Weissleder
Research05 Dec 2016
Nature Chemical Biology

Volume: 13, P: 168-173
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

β-Cyclodextrin nanoparticles carrying an antagonist of the toll-like receptors TLR7 and TLR8 drive the M1 phenotype in tumour-associated macrophages and improve immunotherapy response rates in tumour mouse models when used with checkpoint blockade.

Christopher B. Rodell
Sean P. Arlauckas
Ralph Weissleder
Research21 May 2018
Nature Biomedical Engineering

Volume: 2, P: 578-588

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