Nature Search

TGFβ links EBV to multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

Carl Christoph Goetzke
Mona Massoud
Mir-Farzin Mashreghi
ResearchOpen Access12 Mar 2025
Nature

Volume: 640, P: 762-771
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

Decreased brain coenzyme Q₁₀ levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q₁₀ synthesis in mice and humans with HPDL variants, improving survival and neurological symptoms in HPDL-driven mitochondrial encephalopathy.

Guangbin Shi
Claire Miller
Michael E. Pacold
ResearchOpen Access09 Jul 2025
Nature

Volume: 645, P: 466-474
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Of 12 serology assays tested, four detect antibodies in more than 80% of patients with COVID-19.

Jeffrey D. Whitman
Joseph Hiatt
Alexander Marson
Research27 Aug 2020
Nature Biotechnology

Volume: 38, P: 1174-1183
Diversity, structure and convergent evolution of the global sponge microbiome

Sponges are early-diverging marine organisms that establish complex symbioses with microorganisms. Here, Thomas et al.analyse the microbial communities associated with 81 species of sponges from around the world, shedding light on the ecological and evolutionary drivers of these host-microbe associations.

Torsten Thomas
Lucas Moitinho-Silva
Nicole S. Webster
ResearchOpen Access16 Jun 2016
Nature Communications

Volume: 7, P: 1-12
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Transcriptomic, proteomic and immune repertoire profiling reveals distinct peripheral features of MIS-C and pediatric COVID-19, including elevated soluble spike protein levels, more pronounced type II IFN-dependent gene expression and a higher B cell mutation rate in patients with MIS-C.

Keith Sacco
Riccardo Castagnoli
Luigi D. Notarangelo
Research17 Feb 2022
Nature Medicine

Volume: 28, P: 1050-1062
A rocky planet transiting a nearby low-mass star

A low-mass star that is just 12 parsecs away from Earth is shown to be transited by an Earth-sized planet, GJ 1132b, which probably has a rock/iron composition and might support a substantial atmosphere.

Zachory K. Berta-Thompson
Jonathan Irwin
Anaël Wünsche
Research11 Nov 2015
Nature

Volume: 527, P: 204-207
Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review

Adrina Zhong
Benedict Darren
Helen Dimaras
Reviews03 Aug 2018
Genetics in Medicine

Volume: 23, P: 2270-2280

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