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Showing 1–3 of 3 results
Advanced filters: Author: Michael Gruet Clear advanced filters

  • The prognosis of high-risk neuroblastoma is poor despite the availability of multimodal treatment. Here the authors show that high-risk neuroblastoma is sensitive to indisulam, a selective degrader of the splicing factor RBM39 through the dual targeting of RNA splicing and metabolism.

    • Anke Nijhuis
    • Arti Sikka
    • Hector C. Keun
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.

    • Gerard Minuesa
    • Steven K. Albanese
    • Michael G. Kharas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.

    • Kavitha Ramaswamy
    • Lauren Forbes
    • Alex Kentsis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13