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Showing 1–3 of 3 results
Advanced filters: Author: Michael J McIlwraith Clear advanced filters

  • Single-stranded DNA (ssDNA) in a cell is highly prone to degradation, so cells shield ssDNA from nucleases by coating it with single-strand DNA binding proteins (SSBs). In eukaryotes, the canonical SSB is a heterotrimer known as RPA. This paper characterizes a second SSB from human cells, which is called hSSB1. Unlike RPA, hSSB1 is a single protein. Its primary function seems to be in the cellular response to DNA damage.

    • Derek J. Richard
    • Emma Bolderson
    • Kum Kum Khanna
    Research
    Nature
    Volume: 453, P: 677-681

  • Tumor suppressor protein BRCA2 interacts with RAD51 and functions in homologous recombination, but understanding its precise functions has been hampered by difficulties in purifying such a large protein. Now purified full-length human BRCA2 is shown to bind selectively to ssDNA, to promote RAD51 binding to ssDNA while reducing its association with dsDNA, and to stimulate RAD51-mediated DNA strand exchange.

    • Tina Thorslund
    • Michael J McIlwraith
    • Stephen C West
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1263-1265