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Showing 1–3 of 3 results
Advanced filters: Author: Michael J. Carrozza Clear advanced filters

  • NuA4 is an essential and conserved histone acetyltransferase (HAT) complex. Using electron microscopy supported by biochemical analyses, insights are now gained into its interaction with the nucleosome core particle (NCP). These data indicate that the Epl1 subunit is essential for NCP interaction, whereas the Yng2 subunit positions the acetyltransferase complex relative to specific histone tails.

    • Johnathan R Chittuluru
    • Yuriy Chaban
    • Francisco J Asturias
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1196-1203

  • Recent studies suggest that the Spt16 protein of FACT shuttles H2A–H2B dimers off and on nucleosomes during transcription elongation. By restoring nucleosomes after passage of RNA polymerase II, Spt16 and Spt6 prevent transcription from cryptic promoters in coding regions that would otherwise be expressed in the absence of histones.

    • Michael J Carrozza
    • Thomas Kusch
    • Jerry L Workman
    News & Views
    Nature Structural & Molecular Biology
    Volume: 10, P: 879-880