A combination of SAXS, SANS and FRET is used to explore the solution structures of three different nuclear receptor heterodimeric complexes (RXR with RAR, PPARγ or VDR), bound to different target DNA sequences. The work reveals the asymmetric shape of the complexes and the binding of a single coactivator molecule to RXR in each heterodimer.
- Natacha Rochel
- Fabrice Ciesielski
- Dino Moras
