Hydroxycarboxylic acid receptor 2 (HCAR2) is an attractive drug target to treat inflammation. Here, Shenol et al. discuss recent structural findings that elucidate HCAR2 interactions with multiple orthosteric and an allosteric ligand and with G proteins, providing insight into signaling through this receptor.
- Aslihan Shenol
- Ricardo Tenente
- Thue W. Schwartz
