Nature Search

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close relatives use the DPP4 receptor, several other clades—including all HKU5 bat coronaviruses—rely on ACE2, the same receptor used by SARS-CoV and SARS-CoV-2.

Nicholas J. Catanzaro
Ziyan Wu
Michael Letko
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-16
Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

This study describes the development of an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recently emerged SARS-CoV-2, for receptor usage and their ability to infect cell types from different species. Using it, they confirm human ACE2 as the receptor for SARs-CoV-2 and show that host protease processing during viral entry is a significant barrier for viral entry.

Michael Letko
Andrea Marzi
Vincent Munster
Research24 Feb 2020
Nature Microbiology

Volume: 5, P: 562-569
Bat-borne virus diversity, spillover and emergence

Bats harbour a large number of different viruses, some of which have spilled over to cause human disease. In this Review, Letko, Munster and colleagues discuss the diversity of bat viruses and the factors that determine the emergence of zoonotic viruses from bats.

Michael Letko
Stephanie N. Seifert
Vincent J. Munster
Reviews11 Jun 2020
Nature Reviews Microbiology

Volume: 18, P: 461-471
Discovery and characterization of Sager Creek virus, a new orthohantavirus in prairie voles (Microtus ochrogaster)

Nathaniel Mull
Mert Erdin
Kristian M. Forbes
ResearchOpen Access18 Sept 2025
npj Viruses

Volume: 3, P: 1-9
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

A survey of SARS-CoV-2 RBD antibodies identifies those with activity against diverse SARS-CoV-2 variants and SARS-related coronaviruses, highlighting epitopes and features to prioritize in antibody and vaccine development.

Tyler N. Starr
Nadine Czudnochowski
Gyorgy Snell
Research14 Jul 2021
Nature

Volume: 597, P: 97-102
Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone

Philip L Ballard
Roberta A Ballard
Ian Gross
Research01 Dec 1992
Pediatric Research

Volume: 32, P: 673-678
Selection of viral variants during persistent infection of insectivorous bat cells with Middle East respiratory syndrome coronavirus

Arinjay Banerjee
Sonu Subudhi
Vikram Misra
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-15
Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

Neeltje van Doremalen
Trenton Bushmaker
Vincent J. Munster
ResearchOpen Access21 Aug 2024
npj Viruses

Volume: 2, P: 1-8
ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

Robert J. Fischer
Jyothi N. Purushotham
Vincent J. Munster
ResearchOpen Access02 Mar 2021
npj Vaccines

Volume: 6, P: 1-11

Search

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Bat-borne virus diversity, spillover and emergence

Discovery and characterization of Sager Creek virus, a new orthohantavirus in prairie voles (Microtus ochrogaster)

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Plasma Thyroid Hormones and Prolactin in Premature Infants and Their Mothers after Prenatal Treatment with Thyrotropin-Releasing Hormone

Selection of viral variants during persistent infection of insectivorous bat cells with Middle East respiratory syndrome coronavirus

Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

Search

Quick links

Search

Filter By:

Search

Quick links