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Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

Polyneuropathy causes are difficult to pinpoint. Here, authors used single-nucleus and spatial transcriptomics of 37 human peripheral nerves to identify focal perineurial hyperplasia and endoneurial lipid-associated macrophages in polyneuropathies.

Michael Heming
Anna-Lena Börsch
Gerd Meyer zu Hörste
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy

The clinical detection of fluorescent protoporphyrin IX during glioma-resection surgery can be improved via a microscope that pairs stimulated Raman histology and two-photon excitation fluorescence microscopy.

Mustafa Nasir-Moin
Lisa Irina Wadiura
Daniel A. Orringer
Research10 Jul 2024
Nature Biomedical Engineering

Volume: 8, P: 672-688

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Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy

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