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Author Correction: Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Laurel B. Darragh
Jacob Gadwa
Sana D. Karam
Amendments and CorrectionsOpen Access10 Oct 2024
Nature Communications

Volume: 15, P: 1
A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Karam and colleagues report a phase I/Ib trial in patients with HNSCC treated with neoadjuvant SBRT and anti-PD-L1, and perform high-dimensional analyses of immune correlates of response in the tissue microenvironment and peripheral blood.

Laurel B. Darragh
Michael M. Knitz
Sana D. Karam
ResearchOpen Access25 Nov 2022
Nature Cancer

Volume: 3, P: 1300-1317
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.

Laurel B. Darragh
Jacob Gadwa
Sana D. Karam
ResearchOpen Access16 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Publisher Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Laurel B. Darragh
Michael M. Knitz
Sana D. Karam
Amendments and CorrectionsOpen Access10 Jan 2024
Nature Cancer

Volume: 5, P: 210
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment

EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell and endothelial compartments suggests that ephrinB2 acts as a tumor promoter and EphB4 as a tumor suppressor.

Shilpa Bhatia
Diemmy Nguyen
Sana D. Karam
ResearchOpen Access20 Jun 2022
Nature Communications

Volume: 13, P: 1-21
Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Laurel B. Darragh
Michael M. Knitz
Sana D. Karam
Amendments and CorrectionsOpen Access28 Dec 2022
Nature Cancer

Volume: 4, P: 148
Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC

Khalid N. M. Abdelazeem
Diemmy Nguyen
Sana D. Karam
ResearchOpen Access03 Nov 2024
Oncogene

Volume: 44, P: 130-146
Measurement of mouse head and neck tumors by automated analysis of CBCT images

Benjamin Van Court
Brooke Neupert
Sana D. Karam
ResearchOpen Access25 Jul 2023
Scientific Reports

Volume: 13, P: 1-15

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