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Showing 1–3 of 3 results
Advanced filters: Author: Michael Maceyka Clear advanced filters

  • Sphingosine-1-phosphate (S1P) has a key role in the control of immune cell trafficking and is involved in disorders including cancer and inflammatory diseases. Here, Spiegel and colleagues discuss the ways in which S1P could be therapeutically targeted and highlight recent data from preclinical studies and clinical trials.

    • Gregory T. Kunkel
    • Michael Maceyka
    • Sarah Spiegel
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 688-702

  • Engagement of the tumour-necrosis factor (TNF) receptor results in the assembly of multi-component signalling complexes by adaptor proteins that include TNF receptor-associated factor 2 (TRAF2). Genetic evidence indicates that TRAF2 is needed for the polyubiquitination of receptor interacting protein 1 (RIP1), but direct evidence has been lacking. Here it is shown that the lipid sphingosine-1-phosphate is a co-factor needed for this ubiquitination activity of TRAF2.

    • Sergio E. Alvarez
    • Kuzhuvelil B. Harikumar
    • Sarah Spiegel
    Research
    Nature
    Volume: 465, P: 1084-1088