Nature Search

Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses

Hector Marrero
Michael L. Astion
Richard K. Orkand
Research01 Jun 1989
Nature

Volume: 339, P: 378-380
Reliability of amino acid racemisation dating and palaeotemperature analysis on bones

MICHAEL L. BENDER
Research29 Nov 1974
Nature

Volume: 252, P: 378-379
Controls of the structure of subducted slabs

Michael Gurnis
Bradford H. Hager
Research22 Sept 1988
Nature

Volume: 335, P: 317-321
Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis

Kendal Broadie
Michael Bate
Research28 Jan 1993
Nature

Volume: 361, P: 350-353
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer

Although γδ T cells are known to participate in immune dysregulation in solid tumors, their relevance to human microsatellite-stable (MSS) colorectal cancer (CRC) is less well-studied. Here, using single-cell RNA-sequencing, the authors identify a Vδ1 + T cell subset, which are functionally impaired in MSS CRC via a TIGIT-NECTIN2 interaction.

Victoria Stary
Ram V. Pandey
Nina Pilat
ResearchOpen Access13 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Transcriptional refractoriness is dependent on core promoter architecture

Genes are often transcribed in random bursts followed by long periods of inactivity. Here the authors show, by a light-inducible transcription system in Neurospora, that refractory promoters carry a physical memory of their previous transcription history.

François Cesbron
Michael Oehler
Michael Brunner
Research08 Apr 2015
Nature Communications

Volume: 6, P: 1-11
Author Correction: Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication

Anastasiya Kishkevich
Sanjeeta Tamang
Matthew C. Whitby
Amendments and CorrectionsOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1
Identification of domains of c-Jun mediating androgen receptor transactivation

Scott C Wise
Lori A Burmeister
Lirim Shemshedini
Research29 Apr 1998
Oncogene

Volume: 16, P: 2001-2009
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Weiwu Ren
Robert Pengelly
Andrew J. Bennet
Amendments and CorrectionsOpen Access07 Sept 2018
Nature Communications

Volume: 9, P: 1
Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication

The restart of collapsed replication forks is associated with high rates of genomic rearrangement. Here, the authors show that during restart initiation rearrangements are driven mainly by Rad51, whereas during elongation they rely more on Rad52.

Anastasiya Kishkevich
Sanjeeta Tamang
Matthew C. Whitby
ResearchOpen Access26 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

Reya and colleagues use in vivo CRISPR screens to identify the Stau2 RNA-binding protein as a key regulator of myeloid leukemia growth and progression.

Jeevisha Bajaj
Michael Hamilton
Tannishtha Reya
Research20 Apr 2020
Nature Cancer

Volume: 1, P: 410-422
A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy

Poel et al. introduce the COMMUTE framework for evaluating automatic segmentation models in radiotherapy by combining geometric accuracy, expert assessment, time efficiency, and dosimetric analysis. Results show standardized benchmarks and consensus guidelines are needed to properly assess the clinical readiness of AI segmentation tools.

Robert Poel
Elias Rüfenacht
Ekin Ermiş
ResearchOpen Access31 Jul 2025
Communications Medicine

Volume: 5, P: 1-11
Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7

The scarcity of targetable proteins broadly expressed on cancer cells, but not on healthy cells, is an obstacle for chimeric antigen receptor (CAR)-T cell therapy. Here the authors establish that a functionally impaired version of P2X purinoceptor 7, non-functional P2X7 (nfP2X7), fulfils these criteria, and demonstrate that CAR-T cells targeting nfP2X7 efficiently and selectively kill breast and prostate cancer cells in mouse models.

Veronika Bandara
Jade Foeng
Simon C. Barry
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Peroxiredoxin-2 and STAT3 form a redox relay for H₂O₂ signaling

A redox relay was identified in mammalian cells where the H₂O₂-reactive protein peroxiredoxin-2 oxidizes the transcription factor STAT3, resulting in the formation of transcriptionally inactive disulfide-linked oligomers.

Mirko C Sobotta
Willy Liou
Tobias P Dick
Research24 Nov 2014
Nature Chemical Biology

Volume: 11, P: 64-70
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and structural basis of their inhibitory activity.

Weiwu Ren
Robert Pengelly
Andrew J. Bennet
ResearchOpen Access13 Aug 2018
Nature Communications

Volume: 9, P: 1-12
EMERGENCE OF STATE REGULATION IN V.L.B.W. PREMATURE INFANTS

John Paton
Barbara Fajardo
David Fisher
Research01 Apr 1987
Pediatric Research

Volume: 21, P: 183
Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Genome-wide association studies have identified regions which confer risk of high-grade serous epithelial ovarian cancer. Here the authors use expression quantitative train locus analysis to identify candidate genes and functionally characterise them, identifying a role for HOXD9 in ovarian cancer.

Kate Lawrenson
Qiyuan Li
Matthew L. Freedman
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-14
Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Beatrice Oehler
Katrin Kistner
Heike L. Rittner
ResearchOpen Access14 Jul 2017
Scientific Reports

Volume: 7, P: 1-22
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Anna H. Ou
Sara B. Rosenthal
John R. Kelsoe
ResearchOpen Access23 Feb 2024
Translational Psychiatry

Volume: 14, P: 1-9
Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment

Vanessa Schimek
Katharina Strasser
Rudolf Oehler
ResearchOpen Access04 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-13
Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Thomas Klikovits
Paul Stockhammer
Balazs Hegedus
ResearchOpen Access28 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study

Marion Denos
Yi-Qian Sun
Xiao-Mei Mai
ResearchOpen Access12 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
Bipolar disorders

Bipolar disorders are characterized by acute episodes of mania or hypomania and depression. Psychosis can occur in some patients, and cognitive symptoms, including deficits in executive function and memory, are frequent. In this Primer, Vieta et al. discuss the epidemiology, mechanisms, diagnosis and management of bipolar disorders.

Eduard Vieta
Michael Berk
Iria Grande
Reviews08 Mar 2018
Nature Reviews Disease Primers

Volume: 4, P: 1-16
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer

Sonja Neumeyer
Barbara L. Banbury
Jenny Chang-Claude
ResearchOpen Access24 May 2018
British Journal of Cancer

Volume: 118, P: 1639-1647
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma

N M A White
M Mathews
J J E Doré
ResearchOpen Access29 Sept 2009
British Journal of Cancer

Volume: 101, P: 1107-1113
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9

Search

Facilitation of voltage-gated ion channels in frog neuroglia by nerve impulses

Reliability of amino acid racemisation dating and palaeotemperature analysis on bones

Controls of the structure of subducted slabs

Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer

Transcriptional refractoriness is dependent on core promoter architecture

Author Correction: Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication

Identification of domains of c-Jun mediating androgen receptor transactivation

Shared heritability and functional enrichment across six solid cancers

Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication

Genome-wide association study identifies 30 loci associated with bipolar disorder

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia

A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy

Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7

Peroxiredoxin-2 and STAT3 form a redox relay for H₂O₂ signaling

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

EMERGENCE OF STATE REGULATION IN V.L.B.W. PREMATURE INFANTS

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study

Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment

Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study

Bipolar disorders

Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer

KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

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