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Showing 1–12 of 12 results
Advanced filters: Author: Michael Palmgren Clear advanced filters

  • Cytosolic ion gradients in growing pollen tubes are thought to be required for polar growth. Here the authors show that the Arabidopsis plasma membrane H+ ATPases, AHA6, AHA8, and AHA9, maintain tip-to-shank proton gradients, oscillations in cytosolic pH and actin organization to enable pollen tube elongation.

    • Robert D. Hoffmann
    • Maria Teresa Portes
    • Michael Palmgren
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • P4-type ATPases flip lipids from one side of a membrane to the other. Here Poulsen et al. show that ALA10, a P4 ATPase from Arabidopsis thaliana, internalizes phospholipids from the outside of plant cells and suggest that this uptake may be physiologically important for lipid signalling events.

    • Lisbeth R. Poulsen
    • Rosa L. López-Marqués
    • Michael Palmgren
    Research
    Nature Communications
    Volume: 6, P: 1-14

  • Detailed characterization of the regulatory domain of a plasma-membrane Ca2+-ATPase — a calcium pump — in complex with calmodulin results in a two-step structural model that explains how calmodulin-mediated regulation of pump activation affords highly responsive control over the intracellular calcium concentration in eukaryotes.

    • Henning Tidow
    • Lisbeth R. Poulsen
    • Poul Nissen
    Research
    Nature
    Volume: 491, P: 468-472

  • In plants and fungi, cellular ion homeostasis is powered by the proton pump, a member of the P-type ATPase family. The first X-ray structure of the H+-ATPase is presented, and insight into the mechanism by which protons are transported against an electrochemical gradient is provided.

    • Bjørn P. Pedersen
    • Morten J. Buch-Pedersen
    • Poul Nissen
    Research
    Nature
    Volume: 450, P: 1111-1114

  • Micronutrient deficiency in a cereal-based human diet can have grave consequences. Combining genetics, grafting and multi-elemental image analysis, the authors show how two maternal P1B-ATPases export zinc to the developing seed in Arabidopsis.

    • Lene Irene Olsen
    • Thomas H. Hansen
    • Michael Palmgren
    Research
    Nature Plants
    Volume: 2, P: 1-6

  • CRISPR technology has been widely used in plant genome editing and has great potential in precision breeding. The application of CRISPR technology to food crops provides potential for crop synthetic biology and crop domestication. The authors also discuss the implications of regulatory policy for deployment of the technology in the developing world.

    • Yi Zhang
    • Mathias Pribil
    • Caixia Gao
    Reviews
    Nature Food
    Volume: 1, P: 200-205

  • ApoE is known to be important for lipid nanoparticle function. Here, the authors shows that efficacious coronal ApoE originates from high-density lipoprotein (HDL) particles and, enhances hepatic delivery, making HDL a superior biomarker for lipid nanoparticle potency.

    • Kai Liu
    • Ralf Nilsson
    • Alan Sabirsh
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • ATPases transport ions into and out of cells to maintain ion concentration gradients and control aspects of the cellular environment, such as pH. Structural studies of the Na+,K+-ATPase, which transports Na+ and K+, and the H+-ATPase, which transports H+, have provided insights into their functions in eukaryotic cells.

    • J. Preben Morth
    • Bjørn P. Pedersen
    • Poul Nissen
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 60-70