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Showing 1–6 of 6 results
Advanced filters: Author: Michael Pilsl Clear advanced filters

  • Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to drive pre-initiation complex formation.

    • Michael Pilsl
    • Corinne Crucifix
    • Patrick Schultz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • An integrated structural biology approach combining NMR, cryo-EM, X-ray crystallography and molecular dynamics simulations is implemented to characterise the conformational dynamics and interactions of the eukaryotic RNA exosome complex.

    • Jobst Liebau
    • Daniela Lazzaretti
    • Remco Sprangers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Light-oxygen-voltage (LOV) photoreceptors perceive blue light to elicit spatio-temporally defined cellular responses, and their signalling process has been extensively characterized. Here the authors report that the light signal is still transduced in the absence of a conserved Gln residue, thought to be key.

    • Julia Dietler
    • Renate Gelfert
    • Andreas Möglich
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.

    • Ewan Phillip Ramsay
    • Guillermo Abascal-Palacios
    • Alessandro Vannini
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • RNA polymerase I (Pol I) catalyses the transcription of ribosomal RNA precursors, and its transcription initiation mechanism differs from that of Pol II and Pol III. Here the authors present the cryo-EM structure of a trapped early intermediate stage of promoter-recruited Pol I, which reveals the interactions of the basal rDNA transcription machinery with the native promoter, and discuss the mechanistic implications.

    • Michael Pilsl
    • Christoph Engel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10