The expression of IL1β in triple negative breast cancer (TNBC) has been associated with macrophage-induced immune suppression and cancer progression. Here the authors report that ETS1-driven caspase-1 expression is a feature of TNBC and is required for IL1β-mediated macrophage recruitment and breast cancer growth.
- Weiyue Zheng
- Wanda Marini
- Michael Reedijk