Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 51–61 of 61 results
Advanced filters: Author: Michael Rosbash Clear advanced filters

  • Many aspects of sleep, including the how and why, are still mysterious, especially its relationship to learning and memory. A new study suggests that sleep may serve to reset synaptic potentiation, linking it to homeostatic plasticity.

    • Leslie C Griffith
    • Michael Rosbash
    News & Views
    Nature Neuroscience
    Volume: 11, P: 123-124

  • The Per2 gene is a core component of the circadian clock in mammals. It now seems that the mouse Per2 gene is also involved in suppressing tumours, through other genes that affect cell proliferation and death.

    • Michael Rosbash
    • Joseph S. Takahashi
    News & Views
    Nature
    Volume: 420, P: 373-374

  • The identification of mRNA targets for RNA binding proteins (RBP) in stem cells is difficult due to the limited number of available cells. Here, as a proof-of-principle, the authors adapt the HyperTRIBE method to find that an RBP, MSI2, has increased RNA binding in leukemic compared with normal stem cells for selective regulation of oncogenic genes.

    • Diu T. T. Nguyen
    • Yuheng Lu
    • Michael G. Kharas
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The frq gene, essential for circadian clock function, is shown to differ from most other genes in Neurospora by exhibiting non-optimal codon usage; by contrast, optimization of codon usage is unexpectedly found to affect the structure and function of the coded protein, subsequently impairing circadian feedback loops.

    • Mian Zhou
    • Jinhu Guo
    • Yi Liu
    Research
    Nature
    Volume: 495, P: 111-115

  • HyperTRIBE uses a hyperactive RNA-editing enzyme fused to an RNA-binding protein (RBP) to mark the target RNA transcripts of the RBP by converting adenosine to inosine near the binding sites with increased efficiency and reduced sequence bias.

    • Reazur Rahman
    • Weijin Xu
    • Michael Rosbash
    Protocols
    Nature Protocols
    Volume: 13, P: 1829-1849

  • A pair of Drosophila brain cells is identified and its activation alone is found to induce the fly’s complete feeding motor routine when artificially induced; suppressing or ablating these two neurons eliminates the sugar-induced feeding behaviour, but ablation of just one neuron results in asymmetric movements.

    • Thomas F. Flood
    • Shinya Iguchi
    • Motojiro Yoshihara
    Research
    Nature
    Volume: 499, P: 83-87

  • Transcription termination has a central role in regulating gene expression, maintaining the stability of the transcriptome and controlling pervasive transcription. New insights have recently been gained into the molecular basis of termination and the timely and efficient dismantling of elongation complexes at mRNA-coding and non-coding RNA loci.

    • Odil Porrua
    • Domenico Libri
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 190-202

  • Nonsense-mediated mRNA decay (NMD) degrades mRNAs with abnormally positioned translation termination codons. It is now becoming apparent that NMD targets mRNAs to enable mammalian cells to adjust their transcriptomes and their proteomes to changing physiological conditions and during diverse cellular processes.

    • Søren Lykke-Andersen
    • Torben Heick Jensen
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 665-677