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Advanced filters: Author: Michaela A. Ihle Clear advanced filters

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress

Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replication fork restart, suggesting a potential for anti-aging and regenerative therapies.

Mohankrishna Dalvoy Vasudevarao
Denise Posadas Pena
Gilbert Weidinger
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Multinational proficiency tests for EGFR exon 20 insertions reveal that the assay design matters

Michaela A. Ihle
Carina Heydt
Sabine Merkelbach-Bruse
ResearchOpen Access06 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Overcoming EGFR^G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR^G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase remains susceptible to second-generation inhibitors.

Jana Fassunke
Fabienne Müller
Martin L. Sos
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-13

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