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Showing 1–6 of 6 results
Advanced filters: Author: Michaela Müller-McNicoll Clear advanced filters

  • Berrevoets, Kessler, and colleagues present a smart 3D super-resolution microscopy workflow in tandem with single-particle feature extraction. The authors use this approach to monitor the morphology of an RNA-scaffolded nuclear body, revealing thus far unknown structural features.

    • Enya S. Berrevoets
    • Laurell F. Kessler
    • Mike Heilemann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Every RNA polymerase II transcript receives a 5′-end 7-methylguanosine (m7G) cap, which is rapidly bound by the nuclear cap–binding complex (CBC). Two recent studies now reveal that the CBC associates with a variety of effector proteins that enable it to interrogate nascent RNA, discriminating between distinct RNA subclasses and routing them either toward distinct maturation pathways or toward decay. Thus, the CBC has an early role in policing cellular RNA.

    • Michaela Müller-McNicoll
    • Karla M Neugebauer
    News & Views
    Nature Structural & Molecular Biology
    Volume: 21, P: 9-12

  • The RNA-binding protein SRSF7 autoregulates its protein levels through an intricate negative feedback mechanism that involves translation of two distinct protein halves, termed Split-ORFs; the potential to encode Split-ORFs is also seen in other targets of nonsense-mediated decay.

    • Vanessa Königs
    • Camila de Oliveira Freitas Machado
    • Michaela Müller-McNicoll
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 260-273

  • The mechanisms directing chromatin remodeling complexes to genomic regions have remained elusive. Here, the authors show that lncRNAs direct SWI/SNF to cell type-specific enhancers, investigating an RNA-mediated layer of targeting specificity.

    • James A. Oo
    • Timothy Warwick
    • Matthias S. Leisegang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • TDP-43 aggregates are a hallmark of neurodegeneration. Wagner et al. show that SUMOylation/ubiquitylation of TDP-43, mediated by its recruitment to the promyelocytic leukemia protein nuclear bodies, prevents its aggregation under proteotoxic stresses.

    • Kristina Wagner
    • Jan Keiten-Schmitz
    • Stefan Müller
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1408-1419

  • RNA-binding proteins (RBPs) are crucial for guiding mRNAs through the many steps from transcription to translation and decay. This Review discusses recent insights into the repertoire of RBPs, how they package RNA molecules and how they can connect different processing steps.

    • Michaela Müller-McNicoll
    • Karla M. Neugebauer
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 275-287