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Showing 1–4 of 4 results
Advanced filters: Author: Michal Smida Clear advanced filters

  • ATM is a tumor suppressor often mutated in lung adenocarcinoma. In this study, the authors starting from a synthetic lethal screen, demonstrate that tumor cells with mutations in ATM exhibit increased sensitivity to MEK1/2 inhibition through the modulation of the AKT/mTOR pathway.

    • Michal Smida
    • Ferran Fece de la Cruz
    • Sebastian M. B. Nijman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Osteosarcomas are a heterogenous group of tumours and little is known about how these tumours evolve. Here, Kovac et al. use exome sequencing and discover that although no driver gene explains the majority of these tumours, they are characterized by specific mutation signatures and genomic instability typical of BRCA1/2-deficient tumours.

    • Michal Kovac
    • Claudia Blattmann
    • Daniel Baumhoer
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

    • Markus K Muellner
    • Iris Z Uras
    • Sebastian M B Nijman
    Research
    Nature Chemical Biology
    Volume: 7, P: 787-793

  • A collection of single-gene-mutant human cells is described. This growing resource is based on gene-trap mutagenesis of a near-haploid human cell line and covers almost 3,500 human genes.

    • Tilmann Bürckstümmer
    • Carina Banning
    • Sebastian M B Nijman
    Research
    Nature Methods
    Volume: 10, P: 965-971