Replication at challenging genomic regions like telomeres and centromeres threatens genome stability. Here, the authors reveal that RECQ4 interacts with MUS81 to enhance its activity, subsiding replication stress. Loss of this interaction causes chromosomal instability, with implications for human diseases like RTS.
- Raghib Ashraf
- Hana Polasek-Sedlackova
- Lumir Krejci
