The human proprotein convertases are a family of nine serine proteases that are involved in the processing and modulation of various proteins. Seidah and Prat review the physiological functions and pathological implications of proprotein convertases, highlighting recent advances and associated challenges in the development of novel therapeutics targeting them, including inhibitors of proprotein convertase subtilisin kexin 9 (PCSK9) for the treatment of hypercholesterolaemia.
- Nabil G. Seidah
- Annik Prat
