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Showing 1–8 of 8 results
Advanced filters: Author: Michel DuPage Clear advanced filters

  • This paper illustrates that immunosurveillance and immunoediting can occur in an oncogene-driven endogenous tumour model provided that the tumours carry strong neoantigens not present in the host.

    • Michel DuPage
    • Claire Mazumdar
    • Tyler Jacks
    Research
    Nature
    Volume: 482, P: 405-409

  • Shedding light on epigenetic mechanisms controlling anti-tumor immune responses, a new study shows that the tumor-intrinsic ring finger protein 2 (RNF2), the catalytic subunit of Polycomb repressor complex 1 (PRC1), acts as a negative regulator of a collaborative NK and CD4+ T cell anti-tumor immune response against breast cancer.

    • Janneke G. C. Peeters
    • Michel DuPage
    News & Views
    Nature Cancer
    Volume: 2, P: 996-997

  • In a mouse tumour model, immunotherapy-induced rejection of tumour cells requires presentation of both MHC class I and MHC class II antigens, which activate CD4+ and CD8+ T cells, respectively.

    • Elise Alspach
    • Danielle M. Lussier
    • Robert D. Schreiber
    Research
    Nature
    Volume: 574, P: 696-701

  • Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stability.

    • Alexandria Huynh
    • Michel DuPage
    • Laurence A Turka
    Research
    Nature Immunology
    Volume: 16, P: 188-196

  • T cells are inherently flexible and can acquire distinct functions to combat different pathogens or changing circumstances. However, this flexibility can be deleterious or advantageous depending on the disease setting. Here, the authors describe the molecular mechanisms that regulate CD4+T cell plasticity and how it might be harnessed to treat disease.

    • Michel DuPage
    • Jeffrey A. Bluestone
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 149-163