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Showing 1–2 of 2 results
Advanced filters: Author: Michele Brischigliaro Clear advanced filters

  • Mitochondrial diseases, including those caused by defects in complex III of the respiratory chain, lack curative treatments. Here the authors report that the small molecule pyocyanin has beneficial effects in cells derived from patients with complex III-deficiency as well as in fly and zebrafish genetic models with reduced complex III activity.

    • Roberta Peruzzo
    • Samantha Corrà
    • Ildikò Szabò
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Kverneng et al. assess the mitochondrial respiratory chain in skeletal muscle from persons with Parkinson’s disease. Their findings suggest the existence of a subpopulation with complex I deficiency and support the potential of extra-neural biomarkers for patient stratification.

    • Simon Ulvenes Kverneng
    • Kjersti Eline Stige
    • Charalampos Tzoulis
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-17