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Showing 1–2 of 2 results
Advanced filters: Author: Michelle A. Henstridge Clear advanced filters

  • Terminal patterning of the Drosophila embryo is thought to be regulated by local cleavage of the ubiquitous peptide hormone Trunk (Trk) controlled by the maternal gene torso-like (tsl)that is expressed only at embryo poles. Here, the authors show that cleavage of Trk is indeed required for patterning and can occur independently of Tsl.

    • Michelle A. Henstridge
    • Travis K. Johnson
    • James C. Whisstock
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • Activation of the growth factor Trunk patterns the Drosophila embryonic termini but how this is regulated is unclear. Here, Johnson et al.report that Trunk is cleaved intracellularly by Furin proteases, and its extracellular accumulation is then mediated by the perforin-like protein Torso-like.

    • Travis K. Johnson
    • Michelle A. Henstridge
    • Coral G. Warr
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-6